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KMID : 0358419940370020274
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Korean Journal of Obstetrics and Gynecology
1994 Volume.37 No. 2 p.274 ~ p.286
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Demonstration of Estrogen Receptors in Umbilical Endothelial Cell as Evidence of Direct Effect of Estrogen of Blood Vessels
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박형무
강응택/박용욱/유재형/허민
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Abstract
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It has been reported that estrogens have a protective role on the cardiovascular system, that is, the reduction of the risk of cardiovascular disease which is the most common cause of death in women over 50 years of age in the industrialized
countries.
Postmenopausal estrogen replacement therapy reduces. The risk of coronary heart disease by 30~70% and risk of stroke by 40%.
The exact role of estrogens in the pathogenesis of atherosclerosis and myocardial in farction remains to be defined.
This beneficial effect of hrmone replacement therapy on the cardiovascular disease is mainly mediated by changes in lipid and lipoprotein metabolism such as decreased total and LDL-cholesterol ad increased HDL-cholesterol, which reduce the
atherogenesis. Put other non-lipid mechanisms also appear to be involved.
The current data prove that the vascular endothelium plays a prominent role in the regulation of vascular tone and reactivity by producing several potent locally acting vaso active peptides.
Estrogens have been reported to induce vasodilation in variety of animals. If estrogens are clearly associated with release of certain vasoactive peptides such as prostacyclin or endothelium-derived relaxing factor (EDRF), endothelium may have an
another causative mechanism in addition to muscularis of the blood vessel wall for the expression of estrogen actions on the cardiovascular system.
To prove this hypothesis, we carried out preliminary study about the status of the estrogen receptors in the vascular endothelium immunohistochemically by using the umbilical vein and endothelial cell culture.
Weakly positive reaction of estrogen receptor is noted in the endothelial cells of umbilical veins and arteries in fresh umbilical specimen. Intracytoplasmic and intranuclear positive reaction of estrogen receptor in cultured endothelial cells of
umbilical vein were clearly identified.
These findings suggest that vascular endothelium may be target tissues for estrogen and the effect of estrogens on vascular tissuse may be partially through the actions on endothelium.
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KEYWORD
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